منابع مشابه
Postaxial polydactyly in forelimbs of CRABP-II mutant mice.
The cytoplasmic retinoic acid (RA)-binding protein CRABP-II is expressed widely throughout early morphogenesis in mouse embryo, but its expression becomes more restricted as organogenesis progresses. CRABP-II expression remains strong in the developing limb bud suggesting a role for this protein in limb patterning. Here, we show that the CRABP-II promoter can direct expression of a lacZ transge...
متن کاملPolydactyly and ectopic ZPA formation in Alx-4 mutant mice.
Correct development of the limb is dependent on coordination between three distinct signaling centers. Recently, fibroblast growth factor-4 has been identified as a crucial determinant of AER function, which directs limb bud outgrowth, and Sonic hedgehog has been identified as a signaling molecule that mediates ZPA function, which specifies anterior-posterior patterning in the developing limb b...
متن کاملCyclophosphamide induced polydactyly in mice: understanding of underlying mechanism
Polydactyly with 6 or 7 digits bilaterally, or in all the four limbs at a time in certain cases was the principal finding amongst limb malformations in mice fetuses exposed to cyclophos-phamide in the dose of 10 mg /kg body weight on day 11 of gestation. Duplication of great toe was the most dominant. Augmentation of apoptosis by cyclophosphamide resulting in excessive programmed cell death in ...
متن کاملImpulsive choices in mice lacking imprinted Nesp55.
Genomic imprinting is the process whereby germline epigenetic events lead to parent-of-origin specific monallelic expression of a number of key mammalian genes. The imprinted gene Nesp is expressed from the maternal allele only and encodes for Nesp55 protein. In the brain, Nesp55 is found predominately in discrete areas of the hypothalamus and midbrain. Previously, we have shown that loss of Ne...
متن کاملParturition failure in mice lacking Mamld1
In mice, the onset of parturition is triggered by a rapid decline in circulating progesterone. Progesterone withdrawal occurs as a result of functional luteolysis, which is characterized by an increase in the enzymatic activity of 20α-hydroxysteroid dehydrogenase (20α-HSD) in the corpus luteum and is mediated by the prostaglandin F2α (PGF2α) signaling. Here, we report that the genetic knockout ...
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ژورنال
عنوان ژورنال: Experimental Biology and Medicine
سال: 2008
ISSN: 1535-3702,1535-3699
DOI: 10.3181/0802-rm-48